Lewis Ross Fischer (1946–2018)

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Nicotine behavioral sensitization in Lewis and Fischer male rats.

Individuals with greater nicotine-reactivity may be more likely to initiate and maintain cigarette-smoking behavior than individuals with less nicotine-reactivity. In rats, behavioral sensitization reflects a progressive increase in the psychomotor response to drugs of abuse thought to result from neuroplasticity in brain regions that mediate their motivational effects. Studying nicotine behavi...

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Lewis rats have greater response impulsivity than Fischer rats.

Impulsivity, a tendency toward immediate action without consideration of future consequences, is associated with a wide array of problematic behaviors. Response impulsivity, a type of behaviorally-assessed impulsivity characterized by behavioral disinhibition, is also associated with health risk behaviors. Response impulsivity is distinct from choice impulsivity, which is characterized by intol...

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Spontaneous withdrawal in opiate-dependent Fischer 344, Lewis and Sprague-Dawley rats.

The Lewis (LEW) and Fischer 344 (F344) inbred rat strains react differentially to acute morphine administration for a variety of behavioral and neurochemical measures. Investigations into effects of chronic morphine are less common, and investigations assessing dependence have been limited to those utilizing antagonist-precipitated withdrawal. The present experiment extended these assessments b...

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Impulsive Choice in Lewis and Fischer 344 Rats: Effects of Extended Training

Delay discounting in Lewis and Fischer 344 was compared using a novel concurrent-chains procedure. In the initial-link, two levers were available and a random-interval schedule was in effect. One terminal link provided a smaller reinforcer (1 pellet) and the other terminal provided a larger reinforcer (4 pellets). Terminal-link entry was scheduled randomly, with the constraint that entries to e...

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The differential expression of male sexual behavior in the Lewis, Fischer and Sprague-Dawley rat strains.

Several indices of sexual behavior were characterized for male rats of the Lewis (LEW), Sprague-Dawley (SD) and Fischer (F344) strains. Males were permitted access to a receptive female of their own strain for five 50-min sessions every fifth day. LEW males emitted longer latencies (first mount, intromission, ejaculation and post-ejaculatory interval) and lower frequencies (mounts, intromission...

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ژورنال

عنوان ژورنال: The Mariner's Mirror

سال: 2018

ISSN: 0025-3359,2049-680X

DOI: 10.1080/00253359.2018.1453643